The Philadelphia Chromosome
This illustration was created for JAAPA, February 2013 • 26(2). The Philadelphia chromosome is formed when a piece of chromosome 9 exchanges places with a piece of chromosome 22, resulting in a balanced translocation t(9;22)(q34;q11) and the formation of an abnormal fusion gene BCR-ABL1. Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm. The American Cancer Society estimated that in 2012, the number of newly diagnosed CML cases would be 5,430, with 610 deaths.1 The discovery of the tyrosine kinase inhibitor (TKI) imatinib has revolutionized the treatment and prognosis of CML,...
Read MoreSomaLogic Somamer MOA
This explanatory animation illustrates SomaLogic’s SOMAmer technology. At the heart of SomaLogic’s unique platform are SOMAmer (Slow Off-rate Modified Aptamer) modified nucleic acid-based protein binding reagents, each of which are highly specific for their cognate protein. To date, SomaLogic has developed SOMAmers to a broad array of over 1000 different protein targets critical to normal and disease biology, and continue to add new SOMAmers all the time. SOMAscan™ technology (illustrated below) takes advantage of two distinctive properties of SOMAmers: Their specific...
Read MoreNatural Killer Cells
This illustration was created for a feature article in the October 2011 issue of the Washington University in St. Louis Alumni Magazine article by Steve Kohler. “Professor Wayne Yokoyama, MD, long intrigued by the function of natural killer (NK) cells, has shown that NK cells, using a “licensing strategy,” are vitally important elements of the immune system. In 2010, on the occasion of accepting the Lee C. Howley Sr. Prize for his pioneering arthritis research, Wayne M. Yokoyama, MD, told his audience that real advances in science do not come from the close application of previously...
Read MoreLeukocyte Infiltration in ALS
Leukocyte Infiltration into the Spinal Cord Activates Astrocytes and Microglia causing neuronal stress and apoptosis
Read MoreAngiogenesis Targeting
TTV 02 Angiogenesis Targeting: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Angiogenesis can be targeted by various types of drug agents (EGFR or HER1, VEGF, VEGF receptor and MMP inhibitors) which can interrupt the growth of tumor vasculature. Storyboard, Illustration and Animation by Jennifer Fairman. TTV 02: Angiogenesis Targeting from Fairman Studios on Vimeo. Angiogenesis can be targeted by various types of drug agents (EGFR or HER1, VEGF,...
Read MoreNormal vs. Tumor Vasculature
TTV 01 Normal vs. Tumor Vasculature: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Understanding normal vs. tumor vasculature and the relationship of tumor induced blood vessels with angiogenic mechanisms of action. Storyboard, Illustration & Animation by Jennifer Fairman. TTV 01: Normal vs. Tumor Vasculature from Fairman Studios on Vimeo. Understanding normal vs. tumor vasculature and the relationship of tumor induced blood vessels with...
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