Illustration created for the article Evaluation and Treatment of Painful Total Hip Arthroplasties with Modular Metal Taper Junctions by R. Michael Meneghini, MD; Nadim J. Hallab, PhD; Joshua J. Jacobs, MD. Orthopedics May 2012, Volume 35, Number 5.
Modern primary total hip arthroplasty femoral components have emerged to include modular necks. Subsequently, the additional taper junction provides another interface as a potential source for mechanically assisted crevice corrosion, which is a complex process involving fretting and crevice corrosion. Furthermore, it is becoming evident that an adverse local tissue reaction may result in some patients due to the mechanically assisted crevice corrosion. This article details the clinical, radiographic, and laboratory evaluation of patients with these components who present with persistent pain. The relevant surgical strategies and techniques to address this pathology in symptomatic patients are addressed.
This illustration is one of the latest editorial pieces completed for the American Academy of Family Physicians featuring The Male Wellness Exam.
Depicted are a montage of images illustrating common considerations during history and physical examination during male wellness exams, including weight and obesity screening, colonoscopy screening for colorectal cancer and immunization schedules.
According to the featured article, “The adult well male examination should incorporate evidence-based guidance toward the promotion of optimal health and well-being, including screening tests shown to improve health outcomes. Nearly one-third of men report not having a primary care physician, and 12% rate their overall health as poor. Medical history should include tobacco, alcohol and illicit substance use; risks for sexually transmitted infections ; diet and exercise habits; and symptoms of depression. Physical examination should include blood pressure screening and height and weight measurements. Men with sustained blood pressures greater than 135>80 should be screened for diabetes. Lipid screening is warranted in all men 35 years and older and in men ages 20 to 35 with cardiovascular risk factors. Ultrasound screening for abdominal aortic aneurysm should occur once between ages 65 and 75 in men who have ever smoked. There is insufficient evidence to recommend screening men for osteoporosis or skin cancer. The U.S. Preventive Services Task Force has provisionally recommended against PSA-based screening for prostate cancer because the harms of testing outweigh potential benefits; other organizations advise shared decision making about PSA testing in men age 50 years and older. Screening for colorectal cancer should begin at age 50 for average-risk men and continue until at least age 75 via annual high-sensitivity fecal occult blood testing (FOBT), flexible sigmoidoscopy every 5 years combined with FOBT, or colonoscopy every 10 years. The USPSTF recommends against screening for testicular cancer and chronic obstructive pulmonary disease. Immunizations should be recommended according to guidelines from the Advisory Committee on Immunization Practices.”
This explanatory animation illustrates SomaLogic’s SOMAmer technology. At the heart of SomaLogic’s unique platform are SOMAmer (Slow Off-rate Modified Aptamer) modified nucleic acid-based protein binding reagents, each of which are highly specific for their cognate protein. To date, SomaLogic has developed SOMAmers to a broad array of over 1000 different protein targets critical to normal and disease biology, and continue to add new SOMAmers all the time.
SOMAscan™ technology (illustrated below) takes advantage of two distinctive properties of SOMAmers: Their specific protein-binding properties and their primary nucleic acid sequences. These two properties not only ensure accurate protein detection and measurement, but allow the multiplexing of literally up to more than a thousand such measurements in each of several hundred different samples in a single experiment.
This technology ensures that measurements are taken only of proteins specific to the SOMAmers being used, giving an accurate readout of both protein identity and concentration in the original sample. The ability to detect anywhere from a few to more than a thousand proteins in literally hundreds of different samples a day – depending on the requirements of the analysis being undertaken – provides for a quick determination of a protein biomarker “signature” indicative of the disease or biological state (e.g., drug response) being studied.
SomaLogic Somamer MOA from Fairman Studios on Vimeo.
This illustration is one of the latest editorial pieces completed for the American Academy of Family Physicians featuring Labor Analgesia.
Depicted are a montage of images illustrating Epidural analgesia, a commonly employed technique which provides pain relief during labor. Epidural analgesia is a form of regional analgesia involving injection of drugs through a catheter placed into the epidural space. The injection can cause both a loss of sensation (anaesthesia) and a loss of pain (analgesia), by blocking the transmission of signals through nerves in or near the spinal cord.
The epidural space is the space inside the bony spinal canal but outside the membrane called the dura mater (sometimes called the “dura”). In contact with the inner surface of the dura is another membrane called the arachnoid mater (“arachnoid”). The arachnoid encompasses the cerebrospinal fluid that surrounds the spinal cord.
Adaptive Radiation of the Pollen Peeper (from: An Origin of Species WGBH Evolution Initiatives ) For interactive web module about the evolutionary theory of Adaptive Radiation. The objectives of this project are to explore adaptive radiation, the evolutionary process by which a single species can diversify into many species, all with different adaptive traits, and to understand the factors that push and/or allow for different populations of the same species to diverge and eventually become separate species. Here a fictitious bird, the Pollen Peeper (based similarly to the North American House Finch and the Honey Creeper), is used as a model.
Editorial illustration for Lahey Clinic Magazine Spring 2001 Issue. This illustration summarizes a glossary of headache types which are described in the feature article. Depicted are the sites of common headaches: migraine (blue arrow) cluster (red arrows) and tension type (yellow arrow).
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