Cellular

Snip Vs. Shred: CRISPR, CAS9, CAS3 and Cascade

Posted on Aug 17, 2015 in Cellular, Editorial, Illustration, Molecular

Snip Vs. Shred: CRISPR, CAS9, CAS3 and Cascade

By Alexander Gelfand, for the Johns Hopkins School of Public Health Magazine. © Johns Hopkins University The powerful genome-editing technology known as CRISPR-Cas made headlines this year—partly because many leading biologists called for a moratorium last March against using it to modify the genomes of human embryos, only to discover in April that Chinese scientists had already done just that. But CRISPR-Cas is more than a genetic engineering tool with profound ethical implications. In fact, the tool itself is a modified version of one of several types of naturally occurring bacterial...

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Snip Vs. Shred: CRISPR, CAS9, CAS3 and Cascade

Posted on Aug 17, 2015 in Cellular, Editorial, Illustration, Molecular

Snip Vs. Shred: CRISPR, CAS9, CAS3 and Cascade

By Alexander Gelfand, for the Johns Hopkins School of Public Health Magazine. © Johns Hopkins University The powerful genome-editing technology known as CRISPR-Cas made headlines this year—partly because many leading biologists called for a moratorium last March against using it to modify the genomes of human embryos, only to discover in April that Chinese scientists had already done just that. But CRISPR-Cas is more than a genetic engineering tool with profound ethical implications. In fact, the tool itself is a modified version of one of several types of naturally occurring bacterial...

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Z-Ring Protein Network

Posted on Mar 27, 2015 in Cellular, Editorial, Featured, Illustration, Molecular, what's new

Z-Ring Protein Network

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Diacylglycerol and PIP3 Signaling

Posted on Jul 3, 2014 in Cellular, Editorial, Illustration, Molecular

Diacylglycerol and PIP3 Signaling

Creating cover art and illustrations for MCP, by Rajendrani Mukhopadhyay: ASBMB Today, January 2014 The way Fairman worked on the art for the MCP special issue on posttranslation modications was typical for any project she does. She met with Gerald Hart of Johns Hopkins University, the MCP associate editor overseeing the issue, and ASBMB’s publications director, Nancy Rodnan, whose idea it was to hire a professional medical illustrator. Hart explained the science in the various articles. With input from Mary Chang, MCP’s managing editor, the group focused on the images that were either...

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The Philadelphia Chromosome

Posted on Mar 27, 2013 in Cellular, Editorial, Illustration, Molecular

The Philadelphia Chromosome

This illustration was created for JAAPA, February 2013 • 26(2). The Philadelphia chromosome is formed when a piece of chromosome 9 exchanges places with a piece of chromosome 22, resulting in a balanced translocation t(9;22)(q34;q11) and the formation of an abnormal fusion gene BCR-ABL1. Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm. The American Cancer Society estimated that in 2012, the number of newly diagnosed CML cases would be 5,430, with 610 deaths.1 The discovery of the tyrosine kinase inhibitor (TKI) imatinib has revolutionized the treatment and prognosis of CML,...

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SomaLogic Somamer MOA

Posted on Mar 21, 2012 in Animation, Cellular, Molecular

SomaLogic Somamer MOA

This explanatory animation illustrates SomaLogic’s SOMAmer technology. At the heart of SomaLogic’s unique platform are SOMAmer (Slow Off-rate Modified Aptamer) modified nucleic acid-based protein binding reagents, each of which are highly specific for their cognate protein. To date, SomaLogic has developed SOMAmers to a broad array of over 1000 different protein targets critical to normal and disease biology, and continue to add new SOMAmers all the time. SOMAscan™ technology (illustrated below) takes advantage of two distinctive properties of SOMAmers: Their specific...

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