SomaLogic Somamer MOA

SomaLogic Somamer MOA

This explanatory animation illustrates SomaLogic’s SOMAmer technology. At the heart of SomaLogic’s unique platform are SOMAmer (Slow Off-rate Modified Aptamer) modified nucleic acid-based protein binding reagents, each of which are highly specific for their cognate protein. To date, SomaLogic has developed SOMAmers to a broad array of over 1000 different protein targets critical to normal and disease biology, and continue to add new SOMAmers all the time.

SOMAscan™ technology (illustrated below) takes advantage of two distinctive properties of SOMAmers: Their specific protein-binding properties and their primary nucleic acid sequences. These two properties not only ensure accurate protein detection and measurement, but allow the multiplexing of literally up to more than a thousand such measurements in each of several hundred different samples in a single experiment.

somascan

This technology ensures that measurements are taken only of proteins specific to the SOMAmers being used, giving an accurate readout of both protein identity and concentration in the original sample. The ability to detect anywhere from a few to more than a thousand proteins in literally hundreds of different samples a day – depending on the requirements of the analysis being undertaken – provides for a quick determination of a protein biomarker “signature” indicative of the disease or biological state (e.g., drug response) being studied.

SomaLogic Somamer MOA from Fairman Studios on Vimeo.

Angiogenesis Targeting

Angiogenesis Targeting

TTV 02 Angiogenesis Targeting: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Angiogenesis can be targeted by various types of drug agents (EGFR or HER1, VEGF, VEGF receptor and MMP inhibitors) which can interrupt the growth of tumor vasculature. Storyboard, Illustration and Animation by Jennifer Fairman.

TTV 02: Angiogenesis Targeting from Fairman Studios on Vimeo.

Angiogenesis can be targeted by various types of drug agents (EGFR or HER1, VEGF, VEGF receptor and MMP inhibitors) which can interrupt the growth of tumor vasculature. Storyboard, Illustration and Animation by Jennifer Fairman.

Normal vs. Tumor Vasculature

Normal vs. Tumor Vasculature

TTV 01 Normal vs. Tumor Vasculature: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Understanding normal vs. tumor vasculature and the relationship of tumor induced blood vessels with angiogenic mechanisms of action. Storyboard, Illustration & Animation by Jennifer Fairman.

TTV 01: Normal vs. Tumor Vasculature from Fairman Studios on Vimeo.

Understanding normal vs. tumor vasculature and the relationship of tumor induced blood vessels with angiogenic mechanisms of action. Storyboard, Illustration & Animation by Jennifer Fairman.

The Role of EGFR

The Role of EGFR

MTT 02 The Role of EGFR in Angiogenesis: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Storyboard, Illustration & Animation by Jennifer Fairman. Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. HER1 & HER2 (EGFR) are shown to play a key role in cancer cell proliferation by their signalling cascade within cancer cells. Storyboard, illustration and animation by Jennifer Fairman.

MTT 02: The Role of EGFR from Fairman Studios on Vimeo.

Mechanism of Action animation. HER1 & HER2 (EGFR) are shown to play a key role in cancer cell proliferation by their signalling cascade within cancer cells. Storyboard, illustration and animation by Jennifer Fairman.

Angiogenesis

Angiogenesis

MTT 01 Angiogenesis: Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Storyboard, Illustration & Animation by Jennifer Fairman. Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation.

MTT 01: Angiogenesis from Fairman Studios on Vimeo.

Mechanism of action animation that explains angiogenesis and it’s roll in cancer growth. VEGF factors in anti-angiogenic activity, helping to stop and reverse cancer growth and proliferation. Storyboard, Illustration & Animation by Jennifer Fairman.

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