Diacylglycerol and PIP3 Signaling

Diacylglycerol and PIP3 Signaling

Creating cover art and illustrations for MCP, by Rajendrani Mukhopadhyay: ASBMB Today, January 2014

The way Fairman worked on the art for the MCP special issue on posttranslation modications was typical for any project she does. She met with Gerald Hart of Johns Hopkins University, the MCP associate editor overseeing the issue, and ASBMB’s publications director, Nancy Rodnan, whose idea it was to hire a professional medical illustrator. Hart explained the science in the various articles. With input from Mary Chang, MCP’s managing editor, the group focused on the images that were either schematics or illustrations. They left alone the images that were captured by a camera or a computer.

“One of the things that I strived to do for this journal was to come up with a consistent style,” explains Fairman. For elements that came up repeatedly, such as ubiquitination, acetylation, proteins and organelles, Fairman established a style so that all of the figures throughout the special issue had the same look and feel. Fairman also says she stuck to scientific conventions as much as possible in terms of colors and symbols. “For example, thinking back to my time in organic chemistry in undergrad, in the little molecular model set, oxygen is usually red, carbon is black, and hydrogen is white,” she says. “Whenever we create any visual, we have to keep in mind who the audience is. Because MCP has a scientific audience, I’ve tried to come up with conventions that people are used to seeing.”

Fairman says it can be a challenge to figure out what should be kept in and left out of an illustration. She had a difficult case with one of the figures from the MCP special issue. “e illustration shows a really complicated mechanism, where these different proteins on the cell membrane, endoplasmic reticulum, nucleus, all the different organelles, are interacting with each other,” she says. “Instead of showing every single protein in its correct configuration, the best thing to do to drive home the message is to use color coding. Not worry so much about what those proteins actually look like but focus more on what they do.”

With the cover, Fairman took another tack, because the cover has a different role than figures in the scienfitic articles. The inspiration for the cover art came from figure 1 in the article by Corina Antal and Alexandra C. Newton at the University of California, San Diego, on the dynamics of lipid second messenger phosphorylation. “e cover isn’t necessarily meant to show the whole mechanism in a way that the readers will completely understand it,” says Fairman. “It is supposed to engage them and bring them into the journal, wanting to read that featured article.”

Acknowledgements: Sourceforge Qutemol

Ftz-Z Ring

Ftz-Z Ring

Ftz-Z Ring

 

Awarded Ralph Sweet Member’s Choice Award, Traditional Media at the AMI 2015 Annual Conference
Z-Ring Stabilization and Constriction Rate Modulation of the ZapA-ZapB-MatP Protein Network
Artist: Jennifer E. Fairman, CMI, FAMI
Client: Jie Xiao, PHD, Associate Professor Department of Biophysics and Biophysical Chemistry, JHUSOM
Medium / software used: Adobe Illustrator CC, Adobe Photoshop CC and PDB
Final presentation format: 2-Page inside spread for Johns Hopkins Magazine
Primary audience: Alumni, Educated Lay Public

About this project: This illustration was created to illuminate the unique structure known as the “Z-ring” and its associated proteins of the E. coli bacterium, which support and regulate cell division. Published as a 2-page spread (in “Artifact”, a feature that highlights striking, attention-grabbing images of new discoveries found or developed at Hopkins), it illustrates the peptidoglycan (PG) protein structure of the divisome and elongasome protein complexes (ZapA-ZapB-MatP). The divisome and elongasome are responsible for PG synthesis during cell division and elongation, respectively. FtsZ assembles into the Z-ring that determines the division plane. FtsA assists in the formation of the Z-ring, recruits downstream division proteins to the Z-ring to generate the divisome that divides the cell, and is involved in coordinating cell wall synthesis during cytokinesis.

Recreational Waterborne Illnesses

Recreational Waterborne Illnesses

Recreational Waterborne Illnesses

Project Description

 

Am Fam Physician. 2017 May 1;95(9):554-560.

Summary: Illness after recreational water activities can be caused by a variety of agents, including bacteria, viruses, parasites, algae, and even chlorine gas. These illnesses are more common in summer. Waterborne illnesses are underreported because most recreational activity occurs in unsupervised venues or on private property, and participants tend to disperse before illness occurs. Symptoms of waterborne illness are primarily gastrointestinal, but upper respiratory and skin manifestations also occur. Gastrointestinal symptoms are usually self-limited, and supportive treatment may be all that is necessary. However, some infections can cause significant morbidity and mortality. Cryptosporidium and Giardia intestinalis are the most common cause of gastrointestinal illness and have partial chlorine resistance. Respiratory infections are typically mild and self-limited. However, if legionnaires’ disease develops and is unrecognized, mortality may be as high as 10%. Cellulitis caused by Vibrio vulnificus can result in serious illness, amputation, and death. Early and appropriate antibiotic treatment is important. Chronically ill and immunocompromised persons are at high risk of infection and should be counseled accordingly.

Project Details

Client American Family Physician
Date 2017
Skills Illustration, Editorial
Media Adobe Photoshop

Project Feature

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Project Feature

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